Thermo Fisher Scientific ACAT2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.

Target Information

This gene represents a member of the frizzled gene family, which encodes 7-transmembrane domain proteins that act as receptors for Wnt signaling proteins. The encoded protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains. Unlike other family members, this protein lacks a C-terminal PDZ domain-binding motif. It functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting oncogenic transformation, cell proliferation, and suppression of apoptosis. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.