Thermo Fisher Scientific DAXX Recombinant Rabbit Monoclonal Antibody (23GB1090)
DAXX 단백질을 인식하는 재조합 토끼 모노클로날 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. HEK293F에서 발현되었으며, 액상 형태로 PBS와 글리세롤 버퍼에 보관됩니다. 인간, 마우스, 랫트 반응성이 있으며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1090 |
| Immunogen | A synthetic peptide of human Daxx (253–272AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with various proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, it functions as a transcription repressor binding to sumoylated transcription factors, with repression relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. It associates with centromeres during G2 phase and may regulate apoptosis in the cytoplasm. Its localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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