Thermo Fisher Scientific ErbB4 Recombinant Rabbit Monoclonal Antibody (23GB1245)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:1,000

Product Specifications

Target Information

Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing various cellular responses such as mitogenesis and differentiation.
It functions as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation of itself.
Like other protein kinases, ErbB4 regulates cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.

ErbB4 is predominantly expressed in several breast carcinoma cell lines, as well as in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
High expression levels are observed in T47-D, MDA-MB-453, BT-474, and H3396 cell lines, while intermediate levels are found in MCF-7, MDA-MB-330, and MDA-MB-361.
Low or absent expression is noted in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ErbB4 levels in certain tumor cell lines suggest a potential role in malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.