Thermo Fisher Scientific CTCF Polyclonal Antibody

Thermo Fisher Scientific CTCF Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Small-eared galago

Target Information

Transcriptional factor CTCF is a ubiquitously expressed, 11-zinc finger domain-containing DNA-binding nuclear phosphoprotein. It plays a key role in gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and imprinting control.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains and can associate with HAT- and HDAC-containing complexes to influence transcriptional activation or repression.
It is involved in transactivation of the APPB gene, silencing of c-myc, insulation of human beta-globin and DMI myotonic dystrophy locus, and imprinting control of IGF2 and H19 regions.
CTCF also regulates transcription of Pax6 and IRAK2 promoters, suggesting therapeutic potential.
Mutations in this gene are associated with invasive breast cancers, prostate cancers, and Wilms' tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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