Thermo Fisher Scientific CTCF Polyclonal Antibody
CTCF 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 다양한 종에서 반응 예측됨. IHC 및 파라핀 절편에 적용 가능하며, 항원 친화 크로마토그래피로 정제됨. 4°C 보관, 연구용으로만 사용.
- 카탈로그번호
- IHC00046x (2개 옵션)
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CTCF Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and 700 of human CCCTC-binding factor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Small-eared galago
Target Information
Transcriptional factor CTCF is a ubiquitously expressed, 11-zinc finger domain-containing DNA-binding nuclear phosphoprotein. It plays a key role in gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and imprinting control.
CTCF interacts with the CCCTC motif on DNA using different combinations of zinc finger domains and can associate with HAT- and HDAC-containing complexes to influence transcriptional activation or repression.
It is involved in transactivation of the APPB gene, silencing of c-myc, insulation of human beta-globin and DMI myotonic dystrophy locus, and imprinting control of IGF2 and H19 regions.
CTCF also regulates transcription of Pax6 and IRAK2 promoters, suggesting therapeutic potential.
Mutations in this gene are associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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