Thermo Fisher Scientific E2F1 Polyclonal Antibody
Rabbit에서 유래한 E2F1 폴리클로날 항체로, 인간 E2F1 단백질을 인식합니다. 세포 주기 조절 및 종양 억제 단백질 연구에 적합합니다. 액상 형태로 제공되며 0.2 mg/mL 농도입니다. 연구용으로만 사용 가능합니다.
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- PA582325
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Thermo Fisher Scientific E2F1 Polyclonal Antibody
제품 사양
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human E2F1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789484 |
Product Specific Information
Immunogen sequence:
ISPGKTPSQE VTSEEENRAT DSATIVSPPP SSPPSSLTTD PSQSLLSLEQ EPLLSRMGSL RAPVDEDRLS PLVAADSLLE HVREDFSGLL PEEFISLSPP HEALDYHFGL EEGEGIRDLF DCDFGDL
Target Information
The protein encoded by this gene is a member of the E2F family of transcription factors.
The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain several evolutionally conserved domains found in most members of the family:
- DNA binding domain
- Dimerization domain (interacts with DP transcription factors)
- Transactivation domain enriched in acidic amino acids
- Tumor suppressor protein association domain (embedded within transactivation domain)
E2F1, along with E2F2 and E2F3, has an additional cyclin binding domain.
This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner and can mediate both cell proliferation and p53-dependent/independent apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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