Thermo Fisher Scientific E2F1 Polyclonal Antibody

Thermo Fisher Scientific E2F1 Polyclonal Antibody

제품 사양

Product Specific Information

Immunogen sequence:
ISPGKTPSQE VTSEEENRAT DSATIVSPPP SSPPSSLTTD PSQSLLSLEQ EPLLSRMGSL RAPVDEDRLS PLVAADSLLE HVREDFSGLL PEEFISLSPP HEALDYHFGL EEGEGIRDLF DCDFGDL

Target Information

The protein encoded by this gene is a member of the E2F family of transcription factors.
The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.

E2F proteins contain several evolutionally conserved domains found in most members of the family:

• DNA binding domain
• Dimerization domain (interacts with DP transcription factors)
• Transactivation domain enriched in acidic amino acids
• Tumor suppressor protein association domain (embedded within transactivation domain)

E2F1, along with E2F2 and E2F3, has an additional cyclin binding domain.
This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner and can mediate both cell proliferation and p53-dependent/independent apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.