Thermo Fisher Scientific Phospho-MYL9/MYL12 (Thr17, Ser18) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MLC-2 (Phospho-Thr17+Ser18) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MYL9/MYL12,uniProtId:P24844-1,ncbiNodeId:9606,antigenRange:17|18,antigenLength:172,antigenImageFileName:PA5-64483_MYL9MYL12_P24844-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64483_MYL9MYL12_P24844-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2662481

Product Specific Information

Phospho-MLC-2 polyclonal antibody detects endogenous levels of MLC-2 (Thr17/Ser18): MLC-2A/MYL12B, MLC-2B/MYL12A, and MLC-2C/MYL9.

Target Information

Myosin regulatory light polypeptide 9 is a highly conserved, ubiquitously expressed protein that in humans is encoded by the MYL9 gene. Myosin, a structural component of muscle, are hexameric proteins consisting of two heavy chains and four light chains, including a single pair of nonphosphorylatable light chain subunits and another pair of phosphorylatable light chain subunits.The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. Myosin light chain (Myl) 9 and Myl12 are new functional ligands for CD69. Blockade of CD69-Myl9/12 interactio ameliorates allergic airway inflammation in ovalbumin-induced and house dust mite-induced mouse models of asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.