Thermo Fisher Scientific V-ATPase C1 Polyclonal Antibody
V-ATPase C1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 사용 가능. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 버퍼(40% glycerol) 내 액상 형태로 제공되며, 연구용으로만 사용.
- 카탈로그번호
- PA566075
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human V-ATPase C1 (Recombinant protein control fragment, Product #RP-105065) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2662664 |
Product Specific Information
Immunogen sequence:
VVVPKLNHNDW IKQYETLAEM VVPRSSNVLS EDQDSYLCNV TLFRKAVDDF RHKARENKFI VRDFQYNEEE MKADKEEMNR
- Highest antigen sequence identity to orthologs: mouse 99%, rat 98%
Target Information
ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments in eukaryotic cells.
V-ATPase–dependent acidification is essential for processes such as:
- Protein sorting
- Zymogen activation
- Receptor-mediated endocytosis
- Synaptic vesicle proton gradient generation
V-ATPase consists of:
- V1 domain: three A and three B subunits, two G subunits, and the C, D, E, F, and H subunits (contains ATP catalytic site)
- V0 domain: subunits a, c, c’, c’’, and d
This gene encodes one of two V1 domain C subunit proteins and is ubiquitously expressed. The C subunit is analogous but not homologous to the gamma subunit of F-ATPases. Previously designated as ATP6D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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