Thermo Fisher Scientific Human FGFR3, His Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg, and 20 µg sizes of kinase are not recommended, as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 µL are not recommended. Do not store kinase diluted. If properly stored at -80°C, this product is guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Catalytic Domain, Cytoplasmic

Target Information

FGFR3 is a member of the FGFR family of receptor tyrosine kinases, which regulate a variety of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair. FGFR family members differ in ligand affinities and tissue distribution and are implicated in diseases such as cancer, rheumatoid arthritis, and diabetic retinopathy.

FGFR3 consists of:

• An extracellular region with three immunoglobulin-like domains
• A single hydrophobic membrane-spanning segment
• A cytoplasmic tyrosine kinase domain

The extracellular portion interacts with fibroblast growth factors, triggering downstream signaling cascades that influence mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormones and plays a key role in bone development and maintenance. Mutations in this gene are associated with craniosynostosis and skeletal dysplasia. Three alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.