Thermo Fisher Scientific FGF Receptor 1 Monoclonal Antibody (M19B2)
FGFR1 단백질을 특이적으로 인식하는 mouse monoclonal antibody. Western blot, IHC, IP 등 다양한 응용에 적합. 단백질 A로 정제된 고순도 항체로, 인체 FGFR1 관련 연구에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M19B2 |
| Immunogen | Recombinant human ectodomain of FGFr1 beta expressed in E. coli beginning with proline 23; antigen contained NH₂-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family is involved in diverse biological processes such as mesoderm induction, cell growth and migration, organogenesis, and bone development.
FGFR1 undergoes alternative splicing, producing multiple variants with distinct expression patterns during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are linked to several disorders, including Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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