Thermo Fisher Scientific SCN2A Polyclonal Antibody
SCN2A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA536545
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1002–1052 of human Na⁺ channel protein type II alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553580 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Voltage-gated sodium channels are selective ion channels that regulate sodium ion permeability in excitable cells. During action potential propagation, these channels allow sodium influx, rapidly depolarizing the cell.
Type I and III alpha subunits are mainly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are abundant along axons.
The beta1 subunit of sodium channel type I is expressed in brain, skeletal, and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also found in pyramidal cells of the deep cerebellar nuclei.
Impaired voltage-gated sodium channels are associated with diseases such as myotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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