Thermo Fisher Scientific B7-H3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Immunogen sequence:
LEVQVPEDPV VALVGTDATL CCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FAEGQDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD

Positive Samples:
U-87MG, 293T, A-549, HeLa

Cellular Location:
Membrane, Single-pass type I membrane protein

Target Information

CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that induces proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and stimulates interferon gamma production. Expression can be induced on dendritic cells and monocytes by inflammatory cytokines and is also found in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing. CD276 has therapeutic potential in regulating cell-mediated immune responses to cancer, particularly in combination with anti-angiogenic therapy.

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.