Thermo Fisher Scientific FAM175B Polyclonal Antibody
Human FAM175B 단백질을 인식하는 Rabbit Polyclonal Antibody로 면역조직화학(IHC) 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. BRISC 복합체 연구 및 p53, IFNAR1 관련 세포 신호 연구에 적합.
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Thermo Fisher Scientific FAM175B Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FAM175B. Recombinant protein control fragment (Product #RP-102776). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641321 |
Product Specific Information
Immunogen sequence:
DVEKSERVVE SCQAEVNKLR RQITQRKNEK EQERRLQQAV LSRQMPSESL DPAFSPRMPS SGFAAEGRST LGDA
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 92%
Target Information
FAM175B is a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. It may act as a central scaffold protein assembling BRISC components and retaining them in the cytoplasm.
Functions include:
- Regulation of apoptosis via modulation of Lys-63-linked ubiquitination
- Mitotic spindle assembly and microtubule attachment to kinetochores via deubiquitination of NUMA1
- Deubiquitination of interferon receptor IFNAR1, enhancing its stability and surface expression
- Down-regulation of LPS response via IFNAR1 deubiquitination
- Induction of p53/TP53 in response to DNA damage
- Promotion of USP7-p53 interaction, preventing p53 degradation and enhancing transcriptional regulation and apoptosis
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-58027_FAM175B_Q15018-1_Rabbit.svg, PA5-58027_FAM175B_Q15018-1_Rabbit_PDP.jpeg)
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