Thermo Fisher Scientific FAM175B Polyclonal Antibody
Thermo Fisher Scientific의 FAM175B 폴리클로날 항체는 인간 FAM175B 단백질을 인식하는 Rabbit IgG 항체로, Western blot 및 IHC(P)에서 검증되었습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FAM175B. Recombinant protein control fragment (Product #RP-97156). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.09 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641320 |
Product Specific Information
Immunogen sequence:
ASDPPPPYSD FHPNNQESTL SHSRMERSVF MPRPQAVGSS NYASTSAGLK YPGSGADLPP PQRAAGDSGE DS
Sequence identity:
- Mouse: 88%
- Rat: 88%
Target Information
Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates.
May act as a central scaffold protein assembling the BRISC complex components and retaining them in the cytoplasm.
Plays a role in regulating apoptosis via modulation of Lys-63-linked ubiquitination of target proteins.
Required for normal mitotic spindle assembly and microtubule attachment to kinetochores by deubiquitinating NUMA1.
Involved in interferon signaling via deubiquitination of IFNAR1, enhancing its stability and surface expression.
Down-regulates the response to bacterial LPS through IFNAR1 deubiquitination.
Required for normal induction of p53/TP53 in response to DNA damage, promoting USP7–p53 interaction and preventing p53 degradation, leading to increased p53-mediated transcription and apoptosis.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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