Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), APC-Alexa Fluor 750

Applications

• Flow Cytometry (Flow): Assay-Dependent
• View 4 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 405
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Alexa Fluor 610
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 705
• Qdot 800
• TRI-COLOR
• Request custom conjugation

Product Specific Information

The allophycocyanin (APC)-Alexa Fluor™ 750 dye tandem conjugate allows for multicolor measurements using excitation by lasers that emit from 633 to 650 nm.

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential for T cell signal transduction, differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) acting as a co-receptor with TCR for MHC-I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance, and their differentiation is enhanced by IL-2, IL-12, and TGF-β1.

Analyte Specific Reagent

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