
Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), APC-Alexa Fluor 750
인간 CD8 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, APC-Alexa Fluor 750 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, 633~650 nm 레이저로 여기됩니다. 4°C 암소 보관하며, 다중 형광 분석에 활용 가능합니다.
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Applications
- Flow Cytometry (Flow): Assay-Dependent
- View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B5 |
| Immunogen | Human CD8 |
| Conjugate | APC-Alexa Fluor™ 750 |
| Excitation / Emission Max | 756 / 785 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 10% sucrose, BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10372357 |
Additional Formats
- Unconjugated
- Alexa Fluor 405
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Alexa Fluor 610
- PE-Cyanine5.5
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Qdot 605
- Qdot 655
- Qdot 705
- Qdot 800
- TRI-COLOR
- Request custom conjugation
Product Specific Information
The allophycocyanin (APC)-Alexa Fluor™ 750 dye tandem conjugate allows for multicolor measurements using excitation by lasers that emit from 633 to 650 nm.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential for T cell signal transduction, differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) acting as a co-receptor with TCR for MHC-I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance, and their differentiation is enhanced by IL-2, IL-12, and TGF-β1.
Analyte Specific Reagent
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