Thermo Fisher Scientific L3MBTL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Dog: 77%
• Guinea Pig: 93%
• Horse: 92%
• Human: 85%
• Mouse: 100%
• Rabbit: 85%
• Rat: 100%

Target Information

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain.
L3MBTL1 localizes to condensed chromosomes in mitotic cells, and its overexpression in glioma cell lines causes improper nuclear segregation and cytokinesis, producing multinucleated cells.
It represents a polycomb group gene regulating gene activity, likely via chromatin modification. The protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, acting as a reader of post-translational modifications.
Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.