Thermo Fisher Scientific L3MBTL1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL
• Publications: [References not provided]

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Mouse: 100%

Target Information

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain.
L3MBTL1 is localized to condensed chromosomes in mitotic cells, and overexpression in glioma cell lines results in improper nuclear segregation and cytokinesis, producing multinucleated cells.
It represents a polycomb group gene; the encoded protein regulates gene activity likely via chromatin modification.
Polycomb group proteins specifically recognize and bind mono- and dimethyllysine residues on target proteins, acting as readers of post-translational modification networks.
Alternatively spliced transcript variants encoding different isoforms of L3MBTL1 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.