Thermo Fisher Scientific Human JAK3, GST Tag Recombinant Protein
인간 JAK3 단백질을 GST 태그로 발현한 재조합 단백질로, 키나아제 활성 분석에 적합합니다. 고순도(90%)로 정제되어 있으며, 액상 형태로 제공됩니다. 면역세포 내 JAK-STAT 신호전달 연구용으로 사용됩니다.
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Applications
- Kinase Assay (KA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | 781–1124 |
| Tag | GST-tag |
| Molecular Weight | 67.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | 90% by SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris-HCl (pH 7.5), 0.02% Triton X-100, 50% glycerol, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
- For larger sizes, aliquot preparation may reduce freeze/thaw cycles (aliquots below 20 µL not recommended).
- Do not store kinase diluted.
- Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Catalytic
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and mediates signaling in response to activation of interleukin receptors.
Upon cytokine stimulation (e.g., interferons, interleukins), JAKs are activated via phosphorylation at two adjacent tyrosine residues. Activated JAKs phosphorylate STAT proteins, which then dimerize and translocate to the nucleus to regulate transcription of interferon-stimulated genes.
JAK2 is required for IFN-γ receptor complex initiation, while JAK1 functions as an amplifier. Some studies suggest that Tyk2 and JAK3 may substitute for JAK2 under certain conditions within the IFN-γ receptor complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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