Thermo Fisher Scientific Human JAK3, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, aliquot preparation may reduce freeze/thaw cycles (aliquots below 20 µL not recommended).
• Do not store kinase diluted.
• Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Catalytic

Target Information

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and mediates signaling in response to activation of interleukin receptors.
Upon cytokine stimulation (e.g., interferons, interleukins), JAKs are activated via phosphorylation at two adjacent tyrosine residues. Activated JAKs phosphorylate STAT proteins, which then dimerize and translocate to the nucleus to regulate transcription of interferon-stimulated genes.
JAK2 is required for IFN-γ receptor complex initiation, while JAK1 functions as an amplifier. Some studies suggest that Tyk2 and JAK3 may substitute for JAK2 under certain conditions within the IFN-γ receptor complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.