Thermo Fisher Scientific DCC Polyclonal Antibody
DCC 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트 시료에 반응합니다. Western Blot과 Immunocytochemistry에 적합하며 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 안정적으로 보관 가능합니다.
- 카탈로그번호
- PA5115098
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DCC (Accession P43146), corresponding to amino acid residues H1320–P1370 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899734 |
Product Specific Information
Antibody detects endogenous levels of total DCC.
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.
The cytoplasmic tail interacts with tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction.
The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand.
It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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