Thermo Fisher Scientific TPT1 Polyclonal Antibody
Human TPT1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 알레르기 및 신경퇴행성 질환 연구용으로 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TPT1. Recombinant protein control fragment (Product #RP-102871). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856518 |
Product Specific Information
Immunogen sequence:
MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYM
Target Information
TPT1 (Translationally Controlled Tumor Protein 1) is a 23 kDa member of the TCTP family of calcium-binding proteins. It is localized in the cytoplasm and widely expressed. TPT1 functions as a transcriptional activator, calcium transporter, histamine inducer, and anti-apoptotic caspase-3 inhibitor. This cytokine-like molecule induces release of histamine, IL-4, and IL-13 from basophils, as well as IL-8 secretion and calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and is implicated in neurodegenerative disorders such as Alzheimer’s disease and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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