Thermo Fisher Scientific TrxR2 Recombinant Rabbit Monoclonal Antibody (23GB4925)
TrxR2 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot과 유세포분석에 최적화됨. HEK293F 발현 시스템에서 생산되며, PBS/glycerol 버퍼 내 액상 형태로 제공. 세포 내 산화 스트레스 및 환원 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB4925 |
| Immunogen | A synthesized peptide derived from human TXNRD2 (50–100AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide–disulfide oxidoreductases. All mammalian TrxRs are homologous to glutathione reductase in primary structure, sharing the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) and featuring a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly-).
TrxR is a homodimeric protein, each monomer containing an FAD prosthetic group, a NADPH binding site, and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to the C-terminal SeCys-containing redox center, which then reduces substrates such as thioredoxin. Members of the TrxR family are 55–58 kDa in size and include three isoforms: cytosolic TrxR1, mitochondrial TrxR2, and TrxR3 (also known as Trx and GSSG reductase, TGR).
TrxR plays a key role in protecting cells from oxidative stress and in redox regulation of transcription factors and various biological processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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