Thermo Fisher Scientific DHCR24 Polyclonal Antibody
DHCR24 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. 액상 형태이며 -20°C에서 보관합니다.
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- PA592446
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 227–516 of human DHCR24 (NP_055577.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806505 |
Product Specific Information
Immunogen sequence:
AEIRIIPAKK YVKLRFEPVR GLEAICAKFT HESQRQENHF VEGLLYSLDE AVIMTGVMTD EAEPSKLNSI GNYYKPWFFK HVENYLKTNR EGLEYIPLRH YYHRHTRSIF WELQDIIPFG NNPIFRYLFG WMVPPKISLL KLTQGETLRK LYEQHHVVQD MLVPMKCLQQ ALHTFQNDIH VYPIWLCPFI LPSQPGLVHP KGNEAELYID IGAYGEPRVK HFEARSCMRQ LEKFVRSVHG FQMLYADCYM NREEFWEMFD GSLYHKLREK LGCQDAFPEV YDKICKAARHPositive Samples: U-87MG, HT-29, PC-12, NCI-H460
Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass membrane protein
Target Information
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase that catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Reduced expression has been observed in the temporal cortex of Alzheimer’s disease patients, while overexpression occurs in adrenal gland cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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