Thermo Fisher Scientific TIAM2 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TIAM2 (NP_001010927.1, 1 a.a. approximately 626 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TIAM2,uniProtId:Q8IVF5-1,ncbiNodeId:9606,antigenRange:1-1701,antigenLength:1701,antigenImageFileName:H00026230-D01P_TIAM2_Q8IVF5-1_Rabbit.svg,antigenImageFileNamePDP:H00026230-D01P_TIAM2_Q8IVF5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MEGPRENQDP PPRPLARHLS DADRLRKVIQ ELVDTEKSYV KDLSCLFELY LEPLQNETFL TQDEMESLFG SLPEMLEFQK VFLETLEDGI SASSDFNTLE TPSQFRKLLF SLGGSFLYYA DHFKLYSGFC ANHIKVQKVL ERAKTDKAFK AFLDARNPTK QHSSTLESYL IKPVQRVLKY PLLLKELVSL TDQESEEHYH LTEALKAMEK VASHINEMQK IYEDYGTVFD QLVAEQSGTE KEVTELSMGE LLMHSTVSWL NPFLSLGKAR KDLELTVFVF KRAVILVYKE NCKLKKKLPS NSRPAHNSTD LDPFKFRWLI PISALQVRLG NPAGTENNSI WELIHTKSEI EGRPETIFQL CCSDSESKTN IVKVIRSILR ENFRRHIKCE LPLEKTCKDR LVPLKNRVPV SAKLASSRSL KVLKNSSSNE WTGETGKGTL LDSDEGSLSS GTQSSGCPTA EGRQDSKSTS PGKYPHPGLA DFADNLIKES DILSDEDDDH RQTVKQGSPT KDIEIQFQRL RISEDPDVHP EAEQQPGPES GEGQKGGEQP KLVRGHFCPI KRKANSTKRD RGTLLKAQIR HQSLDSQSEN ATIDLNSVLE REFSVQSLTS VVSEECFYET ESHGKS

Target Information

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.