Thermo Fisher Scientific THRA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

View 26 publications 26 publications

Immunohistochemistry (IHC)

-

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:100

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:200

View 5 publications 5 publications

Immunomicroscopy (IM)

-

View 1 publication 1 publication

Gel Shift (GS)

1:10

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Chicken, Human, Mouse, Rat

Published species

Human, Mouse, Non-human primate, Rat, Sheep, Xenopus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic Peptide: E(403) V F E D Q E V(410) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:THRA,uniProtId:P10827-1,ncbiNodeId:9606,antigenRange:403-410,antigenLength:490,antigenImageFileName:PA1-211A_THRA_P10827-1_Rabbit.svg,antigenImageFileNamePDP:PA1-211A_THRA_P10827-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum, PBS

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_325811

Product Specific Information

PA1-211A detects thyroid receptor (TR) from human, mouse, rat and chicken samples. This antibody does not detect TRv alpha -2 or TR beta-1.

PA1-211A has been successfully used in Western blot, IHC-P, ICC/IF and gel shift procedures. By Western blot, this antibody detects a ~48 kDa protein representing recombinant human TR alpha-1 expressed in E. coli. Gel shift experiments show that this product reacts with TR alpha-1 homodimers and TR alpha-1/retinoic X receptor (RXR) heterodimers.

PA1-211A immunizing peptide corresponds to amino acid residues 403-410 from human TR alpha-1. This sequence is completely conserved between human and rat TR alpha-1.

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.