Thermo Fisher Scientific RELM beta Polyclonal Antibody
RELM beta 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC, ELISA 등에 사용 가능. Human 시료에 반응하며 Protein A로 정제됨. 0.01M TBS, 1% BSA, 50% glycerol buffer에 보관. -20°C에서 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human RELM beta/CCGR, amino acids 24–80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue functions as a tightly regulated energy reserve in animals. Adipocytes produce and secrete several key proteins such as lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) or FIZZ3, is a cytokine secreted specifically by adipocytes. Although its precise function remains unclear, resistin appears to play paracrine roles and is implicated in type 2 diabetes. Elevated serum resistin levels in obese, diabetic mice antagonize insulin action, leading to insulin resistance and glucose intolerance.
Resistin gene expression depends on C/EBP alpha and is regulated by coactivators CBP and p300, which acetylate histones at the resistin promoter to activate transcription. PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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