Thermo Fisher Scientific Glucagon Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEF

Target Information

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus.
The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels.
Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15–20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets.
Pathological manifestations of the glucagon-type peptide residue almost exclusively with the existence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified.
Glucagon-specific antibodies would prove useful as cell and tumor markers applying immunohistochemical techniques, and as analytical tools in qualification of the hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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