Thermo Fisher Scientific C4B Monoclonal Antibody (2E3)
인간 C4B 단백질을 인식하는 마우스 단클론 항체입니다. Western blot과 ELISA에 최적화되어 있으며, GST 태그 결합 재조합 단백질로 면역화되었습니다. PBS 용액 형태로 제공되며, 보존제는 포함되어 있지 않습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- H00000721-M01
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E3 |
| Immunogen | C4B (NP_000583, 1347–1446 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
NNRQIRGLEE ELQFSLGSKI NVKVGGNSKG TLKVLRTYNV LDMKNTTCQD LQIEVTVKGH VEYTMEANED YEDYEYDELP AKDDPDAPLQ PVTPLQLFEGTarget Information
The C4B gene encodes the basic form of complement factor 4, a key component of the classical complement activation pathway. The protein is synthesized as a single-chain precursor that is cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. This trimer facilitates interactions between antigen-antibody complexes and other complement components.
The alpha chain can be further cleaved to release C4 anaphylatoxin, which mediates local inflammation. Deficiency in this protein is associated with systemic lupus erythematosus (SLE). The gene is located in the MHC class III region on chromosome 6, and exists in multiple haplotypes, allowing 1–3 gene copies per individual. Variants include long and short forms due to insertion or absence of a 6.4 kb HERV-K retrovirus in intron 9.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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