Thermo Fisher Scientific C4BPB Monoclonal Antibody (1G9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.1 ng/mL

-

Immunoprecipitation (IP)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1G9

Immunogen

C4BPB (AAH05378, 1 a.a. approximately 251 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C4BPB,uniProtId:P20851-1,ncbiNodeId:9606,antigenRange:1-252,antigenLength:252,antigenImageFileName:H00000725-M01_C4BPB_P20851-1_House_mouse.svg,antigenImageFileNamePDP:H00000725-M01_C4BPB_P20851-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MFFWCACCLM VAWRVSASDE HCPELPPVDN SIFVAKEVEG QILGTYVCIK GYHLVGKKTL FCNASKEWDN TTTECRLGHC PDPVLVNGEF SSSGPVNVSD KITFMCNDHY ILKGSNRSQC LEDHTWAPPF PICKSRDCDP PGNPVHGYFE GNNFTLGSTI SYYCEDRYYL VGVQEQQCVD GEWSSALPVC KLIQEAPKPE CEKALLAFQE SKNLCEAMEN FMQQLKESGM TMEELKYSLE LKKAELKAKL L

Target Information

Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.