Thermo Fisher Scientific CYB561D2 Polyclonal Antibody
Human CYB561D2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, 0.7 mg/mL 농도의 액상 형태로 제공. CYB561D2 연구 및 암 관련 기전 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CYB561D2. Recombinant protein control fragment (Product #RP-100132). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640292 |
Product Specific Information
- Immunogen sequence: MALSAETESH IYRALRTASG A
- Highest antigen sequence identity: Mouse – 95%, Rat – 95%
Target Information
CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein containing six membrane-spanning domains.
It localizes to endosomes and the endoplasmic reticulum in the perinuclear region and includes two heme-binding sites that reduce ferric ions.
CYB561D2 is ubiquitously expressed, with highest levels in lung, liver, and kidney. Although abundant in normal lung bronchial epithelial cells, it is absent in most lung cancers.
The CYB561D2 gene, located on human chromosome 3p21.3, is associated with frequent and early allele loss in many human cancers.
Exogenous expression induces caspase-independent apoptotic and autophagic pathways, synergistically killing tumor cells, suggesting its potential as a therapeutic target in cancer treatment.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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