Thermo Fisher Scientific Phospho-Bcl-2 (Thr56) Polyclonal Antibody
인산화된 Bcl-2 (Thr56)를 특이적으로 인식하는 토끼 폴리클로날 항체로, 인간 시료에 반응합니다. IHC에 적합하며, 단백질 A로 정제된 액상 형태입니다. 세포사멸 조절 연구 및 BCL-2 관련 신호전달 분석에 활용 가능합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence that includes phosphorylation site of threonine 56 (G-H-T(p)-P-H) derived from human Bcl-2 and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS (pH 7.4) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members modulate apoptosis through dimerization. For example, Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak are critical for cytochrome c release from mitochondria, initiating apoptosis. Bax exerts a pro-apoptotic effect, while constitutive expression of BCL-2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma. High BCL-2 expression is observed in neoplastic germinal centers of follicular lymphomas, but not in normal or hyperplastic ones. Two transcript variants of BCL-2 differ in their C-terminal ends, and overexpression has been linked to cancers such as B-cell lymphoma and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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