Thermo Fisher Scientific Human CD180 Synthetic Peptide
Human CD180 단백질의 N-말단 11개 아미노산 서열을 기반으로 한 합성 펩타이드. RP105 관련 연구에서 차단 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며 PBS 버퍼에 BSA와 sodium azide 포함. 인간 CD180 관련 면역학 및 세포 신호 연구용.
- 카탈로그번호
- PEP0373
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 11 amino acids near the amino terminus of human RP105.
PEP-0373 can be used as a blocking peptide with polyclonal antibody PA5-20251.
Target Information
CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of the Toll-like receptor (TLR) family. The CD180 cytoplasmic tail is short and lacks the TIR domain found in other TLRs. CD180 expression depends on coexpression with MD-1 and mirrors that of TLR4 on antigen-presenting cells.
CD180 regulates LPS recognition and signaling in B cells by interacting with the TLR4 signaling complex, inhibiting microbial ligand binding. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increased cell size.
The extracellular domain contains leucine-rich repeats (LRR) and forms part of the RP105/MD-1 receptor complex. CD180 dysfunction has been associated with Kawasaki disease and may contribute to rheumatic disease pathology.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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