Thermo Fisher Scientific Human UNG Synthetic Peptide
인간 UNG1 아미노 말단의 13개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-20265의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며 PBS 버퍼에 0.1% BSA와 0.02% sodium azide 포함. 연구용으로만 사용.
- 카탈로그번호
- PEP0380
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human UNG Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the amino terminus of human UNG1.
PEP-0380 can be used as a blocking peptide with polyclonal antibody PA5-20265.
Target Information
The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB.
The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively), and as a result, the corresponding mRNAs are not resolved as two species in gel electrophoresis.
Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity.
A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues.
The level and expression pattern of UNG1 and UNG2 differ between cell and tissue types. Additionally, the expression of UNG is cell cycle regulated.
The expression and activity of UNG have been found to be generally higher in proliferating compared to nonproliferating tissues and cells.
UNG1 is a 304 amino acid protein, and UNG2 is a 313 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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