Thermo Fisher Scientific BARD1 Polyclonal Antibody
Human BARD1 단백질을 인식하는 Rabbit 폴리클로날 항체로, IHC(P) 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. BRCA1 상호작용 연구에 유용한 연구용 항체입니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BARD1 (Control fragment: Product #RP-96098) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2638473 |
Product Specific Information
Immunogen sequence:
MIQLCSKLRN LLHDNELSDL KEDKPRKSLF NDAGNKKNSI KMWFSPRSKK VRYVVSKASV QTQPAIKKDA SAQQDS
Antigen sequence identity:
- Mouse: 70%
- Rat: 67%
Target Information
This gene encodes a protein that interacts with the N-terminal region of BRCA1. It shares homology with the conserved regions of BRCA1, including the N-terminal RING motif and C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in proteins regulating cell growth, such as tumor suppressors and protooncogenes. BARD1 also contains three tandem ankyrin repeats.
The BARD1/BRCA1 interaction can be disrupted by tumorigenic amino acid substitutions in BRCA1, suggesting their complex formation is essential for BRCA1 tumor suppression. This protein may be a target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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