Thermo Fisher Scientific TGFB1 Monoclonal Antibody (OTI1E12), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a cytokine belonging to the transforming growth factor beta superfamily, widely expressed in tissues.
It is stored in the extracellular matrix as a latent complex with its pro-domain. Activation requires binding of αV integrin to an RGD sequence and mechanical force exertion.
Latent forms consist of TGFB1, TGF-LAP (latency-associated peptide), and LTBP (latent TGF-beta binding protein).
TGF beta-1 regulates cell proliferation, differentiation, adhesion, and migration, acting as both a positive and negative regulator of other growth factors.
Mutations in TGFB1 are associated with Camurati-Engelmann disease and cystic fibrosis. The gene is often upregulated in tumor cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.