Thermo Fisher Scientific VE-cadherin Polyclonal Antibody
VE-cadherin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 세포 간 접착 단백질 연구 및 혈관 내피세포 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | 18 publications |
| Immunohistochemistry (IHC) | – | 13 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | – |
| Immunocytochemistry (ICC/IF) | 5–10 µg/mL | 15 publications |
| ELISA | 0.1–1 µg/mL | – |
| Immunoprecipitation (IP) | – | 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rabbit, Rat, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from a C-terminal region of the human VE-cadherin (vascular endothelial cadherin, cadherin-5, CD144) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533243 |
Product Specific Information
This antibody has been successfully used in western blot, immunofluorescence, immunohistochemistry, and ELISA.
Target Information
VE-cadherin is a member of the cadherin superfamily located in a six-cadherin cluster on chromosome 16. It is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. It functions as a classic cadherin, promoting homophilic adhesion and playing a key role in endothelial cell cohesion and junction organization. An alternative splice variant has been described, but the full-length sequence has not yet been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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