Thermo Fisher Scientific SMAD4 Monoclonal Antibody (3B9)
SMAD4 단백질을 표적하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3B9). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. 액상 형태, 비보존제 포함, -20°C 보관.
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Thermo Fisher Scientific SMAD4 Monoclonal Antibody (3B9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B9 |
| Immunogen | SMAD4 (AAH02379, 1–552 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA ITTSGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSSMMVKD EYVHDFEGQP SLSTEGHSIQ TIQHPPSNRA STETYSTPAL LAPSESNATS TANFPNIPVA STSQPASILG GSHSEGLLQI ASGPQPGQQQ NGFTGQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV DGYVDPSGGD RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR CLSDHAVFVQ SYYLDREAGR APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ AATAQAAAAA QAAAVAGNIP GPGSVGGIAP AISLSAAAGI GVDDLRRLCI LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL HTMPIADPQP LD
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans.
Also known as Smad family member 4, MAD homolog 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains:
- N-terminal MH1 domain (DNA binding)
- C-terminal MH2 domain (protein interaction)
Functional Role:
- Mediates TGF-beta and BMP signaling via heterotrimerization with R-Smads (Smad1, 2, 3, 5, 8)
- Acts as a tumor suppressor by regulating target genes such as Cyclin D1 (downregulation) and collagen (upregulation)
- Dephosphorylation controls nuclear export and nucleocytoplasmic dynamics
Usage Note
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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