Thermo Fisher Scientific DNA Ligase III Polyclonal Antibody
DNA Ligase III 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제되었으며, -20°C에서 보관. 연구용으로 DNA 복구 관련 연구에 적합.
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Applications and Tested Dilutions
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LIG3 (Accession P49916), corresponding to amino acid residues D641–D691 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851912 |
Product Specific Information
This antibody detects endogenous levels of total DNA Ligase III.
Target Information
There are four distinct DNA ligase proteins found in mammalian cells. Their activity is essential for joining DNA strand breaks that occur during replication, repair, and recombination.
DNA Ligase III migrates as a 100 kDa (α-form) protein in somatic tissues, is ubiquitously expressed, and forms a complex with XRCC-1. A 97 kDa (β-form) variant is found in testis.
DNA Ligase III plays a key role in rejoining DNA single-strand breaks and in the base excision repair pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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