Thermo Fisher Scientific PCCA Polyclonal Antibody
Thermo Fisher Scientific의 PCCA Polyclonal Antibody는 인간 PCCA 단백질을 인식하는 토끼 다클론 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능하며, 안정적인 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PCCA. Recombinant protein control fragment (Product #RP-97987). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645245 |
Product Specific Information
Immunogen sequence:
YPLRHKQADI RINGWAVECR VYAEDPYKSF GLPSIGRLSQ YQEPLHLPGV RVDSGIQPGS DISIYYDPMI SKLITYGSDR TEALKRMADA LDNY
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 84%
Target Information
This protein is a key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine. It is probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits. The protein is located in the mitochondrial matrix.
Defects in PCCA are the cause of propionic acidemia type I (PA-1), a life-threatening disease characterized by episodic vomiting, lethargy, ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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