Thermo Fisher Scientific CRACC Recombinant Mouse Monoclonal Antibody (7H1)
Recombinant mouse monoclonal antibody (clone 7H1) targeting human SLAMF7. Validated for IHC, Flow Cytometry, and ELISA. Produced in HEK293 cells, purified by affinity chromatography. Supplied as liquid in PBS with 50% glycerol for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:20–1:200 |
| Flow Cytometry (Flow) | 1:20–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7H1 |
| Immunogen | Recombinant Human SLAMF7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.82 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092472 |
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent, ERK-mediated pathway and may play a role in lymphocyte adhesion. Isoform 3 does not mediate activation.
SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea. Expression is detected in NK cells, activated B-cells, and NK-cell lines, but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at a much lower level than isoform 1. There are three named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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