Thermo Fisher Scientific RRM2B Monoclonal Antibody (6C1)
RRM2B 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(클론 6C1)로, Western blot 및 ELISA에 적합합니다. 인간 시료 반응성이 있으며, 액상 형태로 제공되고 방부제는 포함되어 있지 않습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6C1 |
| Immunogen | RRM2B (NP_056528, 3 a.a. – approximately 84 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DPERPEAAGL DQDERSSSDT NESEIKSNEE PLLRKSSRRF VIFPIQYPDI WKMYKQAQAS FWTAEEVDLS KDLPHWNKLK AD
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, have been discovered.
p53R2 is a p53-inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. It is induced by ultraviolet and gamma irradiation that cause DNA damage. The product of the p53R2 gene is directly involved in the p53 checkpoint for the repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression, making p53R2 an important target of p53 for tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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