Thermo Fisher Scientific NSMCE2 Monoclonal Antibody (OTI4A2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of large and small subunits. The protein functions in nucleotide-excision repair. Defective activity of this protein is associated with xeroderma pigmentosum complementation group E (XPE). Mutation analysis is required to confirm whether the defect in XPE patients lies in this gene or in the gene encoding the small subunit. Additionally, Best vitelliform macular dystrophy maps to the same region on chromosome 11q, but no sequence alterations of this gene have been demonstrated in Best disease patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.