Thermo Fisher Scientific CCDC88A Polyclonal Antibody
Human Girdin(CCDC88A) 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 액상 형태로 제공. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1425 and 1475 of human Coiled-Coil Domain Containing 88A (Girdin, UniProt ID: Q3V6T2-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Girdin (CCDC88A) is a Galpha-interacting protein that enhances activation of protein kinase Akt, remodels the actin cytoskeleton, and is implicated in cell migration and cancer metastasis.
It interacts with Disrupted-in-Schizophrenia 1 (DISC1), a gene associated with psychiatric disorders. DISC1 plays a role in migration and differentiation of dentate granule cells (DGCs) during development.
Depletion or inhibition of Girdin-DISC1 interaction leads to defects in axonal sprouting and mispositioning of DGCs, suggesting Girdin’s role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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