Thermo Fisher Scientific CCDC88A Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CCDC88A (Girdin) protein. Validated for WB and IP applications. Predicted cross-reactivity with mouse. Suitable for studies on cell migration, actin remodeling, and neurogenesis. Supplied as liquid form, 1 m...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1425 and 1475 of human Coiled-Coil Domain Containing 88A (Girdin) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Girdin (CCDC88A) is a Galpha-interacting protein that enhances activation of the protein kinase Akt, remodels the actin cytoskeleton, and is involved in cell migration and cancer metastasis.
Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 plays a role in migration, positioning, and differentiation of dentate granule cells (DGCs) during development. Depletion of Girdin or disruption of the Girdin–DISC1 interaction causes defects in axonal sprouting in the hippocampal CA3 region and abnormal migration of DGCs, suggesting a role for Girdin in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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