Thermo Fisher Scientific Topo II Beta Polyclonal Antibody
Rabbit polyclonal antibody targeting human DNA Topoisomerase II Beta (TOP2B). Suitable for WB, IHC(P), and IP applications. Unconjugated liquid form with 0.20 mg/mL concentration, stored at 4°C. Recommended shelf life is 1 year.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1570 and the C-terminus (residue 1621) of Human DNA Topoisomerase II Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
Target Information
TOP2B (DNA Topoisomerase II Beta) is a protein-coding gene that encodes a DNA topoisomerase enzyme responsible for controlling and altering DNA topology during transcription. This nuclear enzyme plays key roles in chromosome condensation, chromatid separation, and relieving torsional stress during DNA transcription and replication. It catalyzes transient breaking and rejoining of duplex DNA strands to allow strand passage and topology alteration.
Two forms of this enzyme exist due to gene duplication: the beta form (chromosome 3) and the alpha form (chromosome 17). TOP2B functions as a target for anticancer agents, and mutations can lead to drug resistance. Reduced enzyme activity may contribute to ataxia-telangiectasia. Alternative splicing generates multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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