Thermo Fisher Scientific USP11 Polyclonal Antibody
USP11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat에 반응하며, 고순도 Affinity Chromatography 정제. 핵 내 USP11 단백질 연구 및 BRCA2 관련 암 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 70–190 of human USP11 (NP_004642.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.72 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914265 |
Product Specific Information
- Positive test controls: HeLa, 293T, Jurkat, Rat testis
- Immunogen sequence:
PQHEELPGLD SQWRQIENGE SGRERPLRAG ESWFLVEKHW YKQWEAYVQG GDQDSSTFPG CINNATLFQD EINWRLKEGL VEGEDYVLLP AAAWHYLVSW YGLEHGQPPI ERKVIELPNI Q
Target Information
USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the ubiquitin pathway.
Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and the tumor suppressor BRCA2.
Through these associations, USP11 functions to inhibit ubiquitination or remove ubiquitin residues from these proteins.
USP11 is implicated in several X-linked retinal diseases and may play a role in tumor suppression due to its ability to deubiquitinate BRCA2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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