Thermo Fisher Scientific GRASP1 Polyclonal Antibody
GRASP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 적합합니다. 고순도 Affinity Chromatography 정제 제품이며, 인간 시료에 반응합니다. 5.06 mg/mL 농도의 액상 형태로 -20°C에서 보관합니다.
- 카탈로그번호
- PA588318
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 642–841 of human GRIPAP1 (NP_0645223) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804825 |
Product Specific Information
Immunogen sequence:
RSGLEELVLS EMNSPSRTQT GDSSSISSFS YREILREKES SAVPARSLSS SPQAQPPRPA ELSDEEVAEL FQRLAETQQE KWMLEEKVKH LEVSSASMAE DLCRKSAIIE TYVMDSRIDV SVAAGHTDRS GLGSVLRDLV KPGDENLREM NKKLQNMLEE QLTKNMHLHK DMEVLSQEIV RLSKECVGPP DPDLEPGETSPositive Samples: U-87MG, Jurkat, HeLa, HepG2
Cellular Location: Early endosome
Target Information
PDZ domain-containing proteins, such as PSD-95 and GRIP, play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) bind to distinct PDZ domains within GRIP and regulate glutamate receptor function.
GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent studies suggest that GRASP-1 may regulate neuronal ras signaling and contribute to AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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