Thermo Fisher Scientific GRASP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 642-841 of human GRIPAP1 (NP_0645223) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GRASP1,uniProtId:Q4V328-1,ncbiNodeId:9606,antigenRange:642-841,antigenLength:841,antigenImageFileName:PA5-88318_GRASP1_Q4V328-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88318_GRASP1_Q4V328-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5.06 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804825

Product Specific Information

Immunogen sequence: RSGLEELVLS EMNSPSRTQT GDSSSISSFS YREILREKES SAVPARSLSS SPQAQPPRPA ELSDEEVAEL FQRLAETQQE KWMLEEKVKH LEVSSASMAE DLCRKSAIIE TYVMDSRIDV SVAAGHTDRS GLGSVLRDLV KPGDENLREM NKKLQNMLEE QLTKNMHLHK DMEVLSQEIV RLSKECVGPP DPDLEPGETS; Positive Samples: U-87MG, Jurkat, HeLa, HepG2; Cellular Location: Early endosome

Target Information

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.