Thermo Fisher Scientific Doublecortin Monoclonal Antibody (3 e1)
Doublecortin 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3e1). WB, IHC, ICC/IF에 적합하며, 인간·마우스·랫트 등 다양한 종에 반응. Protein G 정제, PBS/50% glycerol 저장, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3 e1 |
| Immunogen | Full length recombinant human Doublecortin protein expressed in and purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 5 mM sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2802652 |
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein that directs neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains that bind microtubules and interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. This interaction is critical for proper microtubule function in the developing cortex. Mutations in the DCX gene cause X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-33102_Doublecortin_O43602-1_House_mouse.svg, MA5-33102_Doublecortin_O43602-1_House_mouse_PDP.jpeg)
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