Thermo Fisher Scientific DENND1C Polyclonal Antibody
Rabbit polyclonal antibody against human DENND1C protein. Validated for Western blot and IHC applications. High specificity due to antigen affinity purification. Supplied as liquid form with 0.4 mg/mL concentration. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:2,500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DENND1C. Recombinant protein control fragment (Product #RP-99239) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640514 |
Product Specific Information
Immunogen sequence:
PLSPEDEGCP WAEEALDSSF LGSGEELDLL SEILDSLSMG AKSAGSLRPS QSLDCCHRGD LDSCFSLPNI PRWQPDDKKL
Highest antigen sequence identity to the following orthologs:
- Mouse: 61%
- Rat: 61%
Target Information
Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 and bind to clathrin and clathrin adaptor protein-2. Thus, connecdenns link RAB35 activation with the clathrin machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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