Thermo Fisher Scientific PSF/SFPQ Polyclonal Antibody
SFPQ(PSF) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. Human에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. Alzheimer’s disease 관련 연구 등 신경퇴행성 질환 연구에 유용합니다.
- 카탈로그번호
- A301320A
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Polypyrimidine tract-binding protein-associated-splicing factor (Splicing factor, proline- and glutamine-rich) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse.
Target Information
SFPQ (also named PSF) encodes a nuclear factor involved in splicing and regulation of gene expression. It likely forms a heteromer with NONO and participates in DNA pairing and DNA break repair.
SFPQ has been identified as a downstream target of tau; nuclear depletion and cytoplasmic accumulation of SFPQ have been observed in neurons and astrocytes of Alzheimer’s disease (AD) brains. Reduced SFPQ levels may correlate with tau pathology, suggesting a key role in neurodegenerative diseases including AD.
SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa molecules in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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