Thermo Fisher Scientific p130Cas Polyclonal Antibody
Thermo Fisher Scientific의 p130Cas Polyclonal Antibody는 인간 및 마우스 시료에서 p130Cas 단백질 검출에 적합한 rabbit IgG 항체입니다. Western blot과 IHC(P)에서 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA583601
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BCAR1. Recombinant protein control fragment (Product #RP-88613) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790754 |
Product Specific Information
Immunogen sequence:
SPQFQSPPAK QTSTFSKQTP HHPFPSPATD LYQVPPGPGG PAQDIYQVPP SAGMGHDIYQ VPPSMDTRSW EGTKPPAKVV VPTRVGQGYV YEAAQPEQDE YD
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signaling via v-Crk and v-Src oncoproteins. It has a unique structure containing an SH3 domain, multiple YXXP motifs, and a proline-rich region. p130Cas is involved in diverse biological processes such as cell adhesion, migration, growth factor stimulation, cytokine receptor engagement, and bacterial infection. Physiological functions include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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