Thermo Fisher Scientific PSMD10 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total PSMD10 protein.

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 non-identical subunits (two rings of seven alpha subunits and two rings of seven beta subunits).
• The 19S regulator includes a base (six ATPase subunits and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
  Proteasomes are widely distributed in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
  The immunoproteasome plays an essential role in processing class I MHC peptides.
  This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described, and pseudogenes have been identified on chromosomes 3 and 20.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.